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GIPR agonism further promotes bone formation [40], has beneficial effects in animal models for atherosclerosis [41,42,43] and neurodegenerative diseases [44, 45], and decreases body weight in obese rodents via inhibition of food intake [46, 47]

[Cited February 5, 2026]

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GLP-1 RAs reduce food intake and inhibit gastric emptying by activating GLP-1R+ cells in the nervous system, resulting in weight loss ( de novo lipogenesis (DNL) in the liver ( in vivo ( In contrast, GLP-1R is present on human hepatocytes, which may regulate hepatic pathological processes directly in MASLD

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Hohe Dosen fhren zu Durchfall und Kopfschmerzen, ber lngere Zeit kann L-Carnitin Arterien und Herz schdigen